"Every surgeon does operations for people who have these abdominal adhesions," says Zindel. They hope to move to trials on human cells, soon, and eventually clinical trials. Macrophages are also present in humans, and the research team believes the response seen in mice is likely to translate to both adults and children. The body doesn't understand that the surgeon will do the critical repair work." "It's possible, that the body is reacting to the surgery, that having the organs exposed to the environment is interpreted as a threat, like an attack from a predator. "We believe the macrophage response has not made the evolutionary leap to understand that surgery is beneficial and not a threat to survival," says Kubes. Both processes were very effective in stopping the adhesions. They either removed the macrophages, or they introduced a drug to block the macrophage stickiness. The researchers also discovered two ways to inhibit this natural response. Whatever they are responding to, it's clear their involvement is causing the scarring problem." "We are still working to understand why the macrophages take on this repair work as they are known for attacking pathogens. Paul Kubes, PhD, principal investigator on the study and professor at the Cumming School of Medicine. "Joel developed a new method using the highly specialized imaging equipment in my lab that gave scientists the first look at what these macrophages are doing in real-time," says Dr. The research published in Science, was conducted in mice and shows the excess scarring is caused by macrophages, a type of white blood cell that rushes to the surgical site to start to repair the injury. "People sometimes require a second surgery." Joel Zindel, MD, University of Bern, Switzerland, and first author on the study who worked on this research as a Swiss National Science Foundation research fellow at the University of Calgary. Complications from these peritoneal adhesions cause pain and can lead to life-threatening small bowel obstruction, and infertility in women," says Dr. Researchers at the University of Calgary and University of Bern, Switzerland, have discovered what's causing the excess scarring and options to try to prevent it. When the lining gets damaged, tissue and scarring can form, creating problems. It also contains fluid to keep the organs lubricated. The peritoneal cavity has a protective lining containing organs within our abdomen. Excess scarring after abdominal and pelvic surgery within the peritoneal cavity can lead to serious complications and sometimes death. view moreĬredit: Supplied by Kubes' Lab, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary Image: This is the view through a multi-photon microscope as macrophages (red) congregate at an injury site (green).
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